Abstract
A novel mitochondrion-targeted Hg2+-specific fluorescent probe 1 based on ESIPT phthalimide was designed and synthesized for the first time. Owing to the blockage of the ESIPT process between the hydroxy group and the carbonyl oxygen of the imide by the diphenylphosphinothioate group, 1 was almost nonfluorescent. After reacting with Hg2+, 1 exhibited a dramatic fluorescence enhancement due to the recovery of the ESIPT process through Hg2+-induced desulfurization-hydrolysis of the diphenylphosphinothioate moiety and the cleavage of the P-O bond. 1 showed a large Stokes shift, rapid response and high sensitivity and selectivity for Hg2+ over other metal ions. Moreover, 1 was successfully employed to image Hg2+ in the mitochondria of living cells.
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