Abstract
A novel mitochondria-targeting ratiometric probe (IRP) for−OCl based on an imidazo[1,5-a]pyridine-rhodamine FRET platform was developed.
Highlights
Reactive oxygen species (ROS) are of scienti c interest since they could mediate a number of biological processes
A ratiometric fluorescent probe (IRP) for ÀOCl was designed based on the fluorescence resonance energy transfer (FRET) platform
Probe IRP was synthesized via a simple process (Scheme 1) and characterized by 1H NMR, 13C NMR and High-resolution mass spectroscopy (HRMS) (Fig. S1–S3, Electronic supplementary information (ESI)†)
Summary
Reactive oxygen species (ROS) are of scienti c interest since they could mediate a number of biological processes. A ratiometric fluorescent probe (IRP) for ÀOCl was designed based on the fluorescence resonance energy transfer (FRET) platform. IRP was applied to image endogenous ÀOCl with a mitochondria-targeting ability, due to the introduction of the quaternized pyridine moiety.
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