Abstract
Background. Sugammadex offers a good alternative to the conventional decurarisation process currently performed with cholinesterase inhibitors. Sugammadex, which was developed specifically for the aminosteroid-structured rocuronium and vecuronium neuromuscular blockers, is a modified cyclodextrin made up of 8 glucose monomers arranged in a cylindrical shape. Methods. In this study, the goal was to investigate the efficacy of sugammadex. Sugammadex was used when there was insufficient decurarisation following neostigmine. This study was performed on 14 patients who experienced insufficient decurarisation (TOF <0.9) with neostigmine after general anaesthesia in the operating rooms of a university and a state hospital between June, 2012, and January, 2014. A dose of 2 mg/kg of sugammadex was administered. Results. Time elapsed until sugammadex administration following neostigmine 37 ± 6 min, following sugammadex it took 2.1 ± 0.9 min to reach TOF ≥0.9, and the extubation time was 3.2 ± 1.4 min. No statistically significant differences were detected in the hemodynamic parameters before and after sugammadex application. From the time of administration of sugammadex to the second postoperative hour, no side effects or complications occurred. None of the patients experienced acute respiratory failure or residual block during this time period. Conclusion. Sugammadex was successfully used to reverse rocuronium-induced neuromuscular block in patients where neostigmine was insufficient.
Highlights
In addition to their role in successful endotracheal intubations, muscle relaxants are important in making surgical interventions safer, more comfortable, and quicker [1]
Train of four (TOF) electrodes was fixed to the ulnar edge of the distal forearm, a temperature probe was placed on the palm, and the transducer was put on the inner side of the thumb
We investigated the use of sugammadex for cases in which neostigmine was insufficient to reverse the effects of neuromuscular blocking agents (TOF < 0.9)
Summary
In addition to their role in successful endotracheal intubations, muscle relaxants are important in making surgical interventions safer, more comfortable, and quicker [1]. Postoperative residual curarisation following muscle relaxant use is defined as the presence of nicotinic receptors that remain blocked in postoperative patients. The cholinesterase inhibitor agents used for conventional decurarisation have many adverse effects. Sugammadex offers a good alternative to the conventional decurarisation process currently performed with cholinesterase inhibitors. Sugammadex was used when there was insufficient decurarisation following neostigmine. This study was performed on 14 patients who experienced insufficient decurarisation (TOF < 0.9) with neostigmine after general anaesthesia in the operating rooms of a university and a state hospital between June, 2012, and January, 2014. From the time of administration of sugammadex to the second postoperative hour, no side effects or complications occurred. Sugammadex was successfully used to reverse rocuronium-induced neuromuscular block in patients where neostigmine was insufficient
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