Abstract
With the advent of integrated electronics, microfabrication and novel chemistry, NMR (Nuclear Magnetic Resonance) methods, embodied in miniaturized spectrometers, have found profound uses in recent years that are beyond their conventional niche. In this work, we extend NMR relaxometry on a minute sample below 20 μL to challenging environment of 150 °C in temperature and 900 bar in pressure. Combined with a single-board NMR spectrometer, we further demonstrate multidimensional NMR relaxometries capable of resolving compositions of complex fluids. The confluence of HTHP (high-pressure high-temperature) capability, minimal sample volume, and reduced sensor envelop and power budget creates a new class of mobile NMR platforms, bringing the powerful analytical toolkit in a miniaturized footprint to extreme operating conditions.
Highlights
NMR, considered as one of the most potent analytical methods, traditionally demands superconducting magnets[1], sizable electronics, and intricate probe and antenna placements[2,3]
We hereby report the development of a miniaturized NMR platform that is capable of carrying out high-quality relaxation measurements within a micro-autoclave up to 150 °C and 900 bar hydraulic pressure
We further show an integrated system, based on an NMR-ASIC (Application Specific Integrated Circuitry) chipset[6] and a pressure-compensated NMR probe, that can perform a wide range of NMR measurements on a rich diversity of complex fluids
Summary
With the advent of integrated electronics, microfabrication and novel chemistry, NMR (Nuclear Magnetic Resonance) methods, embodied in miniaturized spectrometers, have found profound uses in recent years that are beyond their conventional niche. While applications of NMR abound at elevated pressure and/or temperature settings, such as in subsurface explorations[24], polymer dynamics[25,26], catalysis[27], hydrogen storage[28], and gas adsorption in nanoporous materials[29,30], those measurements always demand complex mechanical designs, large space and numerous pieces of equipment. In this context, miniaturized and integrated NMR platforms with HTHP (high-temperature, high-pressure) capability could further the technique to a substantially broadened usage.
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