Abstract
This paper describes a miniaturized multisensor platform (MP-ISES) consisting of electrodes: a reference one (RE) and ion-selective electrodes (ISEs) for monitoring Na+, K+, Ca2+, Mg2+, Cl−, and SCN− ions and pH in human saliva. Gold electrode surface was modified by deposition of two layers: electrosynthesized PEDOT:PSS forming an intermediate layer, and ion-selective membrane. The developed ISEs were characterized by a wide linear range and sensitivity consistent with the Nernst model. The entire MP-ISEs are characterized by satisfactory metrological parameters demonstrating their applicability in biomedical research, in particular in measurements concerning determination of ionic profiles of saliva. Saliva samples of 18 volunteers aged from 20 to 26 participating in a month experiment had been daily collected and investigated using the MP-ISEs assigned individually to each person. Personalized profiles of ions (ionograms) in saliva, such as Na+, K+, Ca2+, Mg2+, Cl−, SCN−, and H+, were obtained.
Highlights
Direct potentiometry and ion-selective electrodes have been useful tools for determining ion concentration in human body fluids [1,2,3], since they have still been used in medical analyses for determination of Na+, K+, Ca2+, and Cl− ions [4,5,6]
This paper presents the results of the research carried out using the miniature multisensor platform of own construction composed of solid-contact ion-selective electrodes
Since the reference one (RE) in the MP-ion-selective electrodes (ISEs) is of own construction, the performance of ISE was compared with results obtained for measurements versus standard commercial RE (Table 1)
Summary
Direct potentiometry and ion-selective electrodes have been useful tools for determining ion concentration in human body fluids [1,2,3], since they have still been used in medical analyses for determination of Na+, K+, Ca2+, and Cl− ions [4,5,6]. This paper presents the results of the research carried out using the miniature multisensor platform of own construction composed of solid-contact ion-selective electrodes. Our previous article focused on examining some factors influencing ISE response, including lifetime parameters, and showed the algorithm that allows designing ionic composition of solutions for calibration of MP-ISEs. The purpose of this work demonstrates applicability of the developed MP-ISES, in particular as a useful analytical tool for simultaneous determination of ions in saliva.
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