Abstract
Background: Clausena indica (Dalzell) Oliv. belongs to Rutaceae family and it is native to South and South-East Asia. The plant is used in the traditional medicine to treat malaria, rheumatism, bone fracture etc. Objective: In the present review, the previous reports on C. indica concerning its ethnobotanical uses, morphological description, eco-geographical features, phytochemistry and pharmacological effects are summarized Methods: Science-Direct, PubMed, Springer, Scopus and Google-Scholar were used to find potentially relevant literature. The collected literature was analyzed and potential titles were included for screening the abstracts and checking the full texts. After screening 90 potentially interesting articles and other related literature, a reference list of about 39 articles were selected. The reviews, dissertations and other literature without any original research were excluded. Conclusion: The present review describes the ethnomedicinal uses, reported phytochemical compounds isolated from the plant species and various pharmacological properties of C. indica. Ethnomedicinal studies indicated the use of C. indica for the treatment of various diseases. Pharmacological reports showed that C. indica exhibited significant antidiabetic, antioxidant, antimicrobial, free radical scavenging, anti-gout and anticancer effects. Detailed phytochemical studies and molecular gene expression studies are required to explain the exact mechanism of action of active phytocompounds.
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