A Mini-Review on Cell Cycle Regulation of Coronavirus Infection.

Mingjun Su,Li Feng,Shanshan Qi,Dongbo Sun,Yaping Chen,Da Shi

doi:10.3389/fvets.2020.586826

Abstract

Coronaviruses are widespread in nature and infect humans, mammals and poultry. They cause harm to humans and animals. Virus-mediated cell cycle arrest is an essential strategy for viral survival and proliferation in the host cells. A clarification system of the mechanisms of virus-induced cell cycle arrest is highly desirable to promote the development of antiviral therapies. In this review, molecular mechanisms of coronavirus-induced cell cycle arrest were systematically summarized. Moreover, the common features of coronavirus-mediated cell cycle arrest were discussed. This review will provide a theoretical basis for further studies on the infection mechanisms and prevention of coronaviruses.

Highlights

Coronaviruses (CoVs) are the largest positive-sense, single-stranded RNA viruses
Several large-scale epidemics of human and animal CoVs have occurred over the last few decades, especially the SARS-CoV outbreak in 2003, the Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in 2012, and the current global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has threatened global public health security
Several viruses often interfere with the normal cell cycle progression to obtain sufficient resources for viral replication by inducing host cell cycle arrest in an active metabolic state, such as the DNA synthesis phase [2,3,4]

Summary

INTRODUCTION

Coronaviruses (CoVs) are the largest positive-sense, single-stranded RNA viruses. CoVs belong to the Coronaviridae family of the Nidovirales order. Several viruses often interfere with the normal cell cycle progression to obtain sufficient resources for viral replication by inducing host cell cycle arrest in an active metabolic state, such as the DNA synthesis phase [2,3,4]. Coronaviruses Manipulate Host Cell Cycle that CoVs such as transmissible gastroenteritis virus (TGEV), PEDV, murine hepatitis virus (MHV), SARS-CoV, and IBV induce cell cycle arrest to facilitate viral replication [5,6,7,8,9,10,11,12,13,14,15,16,17,18,19]. We aimed to summarize molecular mechanisms that are used by CoVs to manipulate the cell cycle and to provide insights into the common features of CoVmediated cell cycle arrest

Cell Cycle and Regulation

Cell Cycle Regulation of CoVs Infection

Cell cycle arrest by coronaviruses

NA NA

Cell Cycle Regulation by N Protein of CoVs