Abstract
Goals: The development of new treatment for drug abuse requires identification of targetable molecular mechanisms. The pathology of glutamate neurotransmission system in the brain reward circuit is related to the relapse of multiple drugs. Glutamate transporter regulates glutamate signaling by removing excess glutamate from the synapse. And the mechanisms between glutamate transporter and drug addiction are still unclear.Methods: A systematic review of the literature searched in Pubmed and reporting drug addiction in relation to glutamate transporter. Studies were screened by title, abstract, and full text.Results: This review is to highlight the effects of drug addiction on glutamate transporter and glutamate uptake, and targeting glutamate transporter as an addictive drug addiction treatment. We focus on the roles of glutamate transporter in different brain regions in drug addiction. More importantly, we suggest the functional roles of glutamate transporter may prove beneficial in the treatment of drug addiction.Conclusion: Overall, understanding how glutamate transporter impacts central nervous system may provide a new insight for treatment of drug addiction.
Highlights
Drug addiction is a chronic and recurrent mental disorder characterized by compulsive and uncontrollable drug use and addiction behavior [1]
In this review, we suggest that the role of different types of VGLUTS in different brain regions in drug addiction shown in Figure 2
In this review, we also find that whether glutamate transporters can be targets for drug addiction remains to be studied (Tables 1, 2)
Summary
Magistretti, King Abdullah University of Science and Technology, Saudi Arabia. Reviewed by: Silmar Teixeira, Federal University of Piauí, Brazil Jong-Min Kim, Seoul National University Bundang Hospital, South Korea. Specialty section: This article was submitted to Movement Disorders, a section of the journal Frontiers in Neurology. A Mini-Review of the Role of Glutamate Transporter in Drug Addiction. Goals: The development of new treatment for drug abuse requires identification of targetable molecular mechanisms. The pathology of glutamate neurotransmission system in the brain reward circuit is related to the relapse of multiple drugs. Glutamate transporter regulates glutamate signaling by removing excess glutamate from the synapse. The mechanisms between glutamate transporter and drug addiction are still unclear
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