Abstract
Cancer is among the most life-threatening diseases worldwide. Along with conventional therapies like chemotherapy, surgery, and radiotherapy, alternative treatment approaches such as traditional Chinese medicine have attracted considerable public and scientific interest that could be beneficial for patients diagnosed with cancer. Salvia miltiorrhiza Bunge is greatly beloved for its roots and is extensively applied for various disease therapies, including cancers in traditional Chinese medicine. In this review, we intend to summarize the anti-cancer properties of Cryptotanshinone (CPT), an extract of Danshen (the root of Salvia miltiorrhiza Bunge), on different types of cancer.
Highlights
Salvia miltiorrhiza Bunge, a member of the genus Salvia (Lamiaceae family) and referred to as Chinese sage or red sage, is a popular traditional Chinese medicinal plant (Tan et al, 2004; Zhou et al, 2005; Fang et al, 2008)
Li et al (2015) suggested that CPT could have an effect on treatment and prevention of colorectal cancer by inhibiting the activation of signal transducer and activator of transcription 3 (Stat3) pathways
Stat3 plays a role in the expression of various genes, which are in relation to inflammation, cell growth, and other cellular processes and could promote several cancer types such as colorectal cancer (Kamran et al, 2013)
Summary
Salvia miltiorrhiza Bunge, a member of the genus Salvia (Lamiaceae family) and referred to as Chinese sage or red sage, is a popular traditional Chinese medicinal plant (Tan et al, 2004; Zhou et al, 2005; Fang et al, 2008). Its dry root is known as Dansam in Korean, Danshen in Chinese, and Tansen in Japanese (Cheng, 2007) It is a perennial deciduous plant with branched roots, purple flowers, oval leaves, (Ji et al, 2000). Is commonly distributed in northeastern China, Japan, and Korea (Ji et al, 2000; Clebsch, 2003) It has been used in traditional Chinese medicine (TCM) for various conditions such as cerebrovascular disease, cardiovascular disease (Cheng, 2007), hepatitis, apoplexy, immunological disorders (Wang et al, 2014), liver dysfunction (Wasser et al, 1998), renal disease (Ahn et al, 2010), diabetic vascular complications (Cheng, 2007), and used as a dietary supplement for health improvement (Sung et al, 2015).
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