A mild Deprotection of Isopropylidene Ketals from 2-Deoxyglycosides Using AcOH/H2O/DME: An Efficient Regioselective Deprotection of Terminal Isopropylidene Ketals

Abstract

This paper describes a mild and efficient catalytic deprotection method for isopropylidene ketals and benzylidene acetals using AcOH/H2O/DME(1,2-Dimethoxyethane). The method effectively removes ketal and acetal protecting groups from 2-deoxyglycosides which are prone to hydrolysis under acidic conditions. Moreover, it enables the selective removal of the terminal ketal over an internal one.