A mild and highly efficient Friedländer synthesis of quinolines in the presence of heterogeneous solid acid nano-catalyst

Abstract

A simple highly versatile and efficient synthesis of various poly-substituted quinolines in the Friedländer condensation of 2-aminoarylketones with carbonyl compounds and β-keto esters using Montmorrilonite K-10, zeolite, nano-crystalline sulfated zirconia (SZ) as a catalyst in ethanol at moderate temperature. The advantages of methods are short reaction times and milder conditions, easy work-up and purification of products by non-chromatographic methods. The catalysts can be recovered for the subsequent reactions and reused without any appreciable loss of efficiency.