Abstract
An efficient and environmental friendly Pd-catalyzed carboxylate-directed C–H arylation reaction of aryl carboxylic acids with iodobenzenes has been developed in water where Tween 20 was added (2% w/w) to form aqueous micelles to increase the solubility of starting materials. In this aqueous protocol, the reactions proceeded at a lower temperature (80°C) compared with the traditional procedures using organic solvents (100°C and above) and wide substrate scopes were demonstrated (15 examples, 62–92% yields).
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