Abstract
Facile synthesis and smart designs of multifuctional nanocarriers would make them more potential in the practical application of drug delivery for cancer treatment. In this study, we synthesized hollow-mesoporous cobalt ferrite (H-mCoxFe3−xO4) nanoparticles by a cetyltrimethylammonium bromide (CTAB)-assisted solvothermal method. The resulting monodisperse CoxFe3−xO4 microspheres are 280 nm in diameter with fine uniformity and hollow-mesoporous structure, and they possess a fairly high surface area of 58.03 m2/g, a pore volume of 0.13 cm3/g, an average pore size of 7.21 nm, and are suitable for drug loading. This material has a high magnetization saturation value (42.2 emu/g) for drug targeting and its sodium chloride suspension could raise to 50 °C from room temperature in 180 s. The drug release process shows that the release rate under the microwave irradiation was faster than that under stirring condition, and about 64% VP16 was released after six on/off microwave treatment cycles. So these multifunctional H-mCoxFe3−xO4 nanoparticles with single material are expected to provide the research foundation for using as drug carrier themselves for drug loading, magnetic targeting, and microwave-triggered controllable release.
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