Abstract
A rapid and simple microscale method for the determination of octanol-water partition coefficients has been developed and evaluated for a series of twenty-six bioactive 2-amino-2-oxazolines. Solutes were equilibrated between n-octanol and water by using the shake-flask approach in a single partitioning. The concentration of each compound was measured in the aqueous phase before and after partitioning directly by RP-HPLC, and the peak areas ratio was used to calculate the partition coefficient log P. Log P values ranging from -0.22 to 3.69 have been determined with a precision better than ± 0.06 log unit. They were compared with the measured shake-flask octanol-water partition coefficient and with the calculated incremental Clog P values. The linear regression analyses between these lipophilic parameters show significant correlations, allowing validation of this chromatographic approach for the log P determination.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Liquid Chromatography & Related Technologies
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
