Abstract
The electrical properties of cells have long been regarded as potential label-free biophysical markers in cell status evaluation. However, previous studies have focused on the electrical properties of cell populations. Single-cell analysis, which can provide unique insight into the heterogeneous behaviors of cells, is otherwise concealed within the averaged response of a cell population. The mature approach to the study of the electrical properties of single cells has not yet been proposed. This paper reports a microfluidic-integrated optically-controlled electrodes chip for real-time charactering electrical impedance of single cell. An equivalent circuit model for extracting the impedance of single cell was proposed and discussed. The impedance of C2C12, which is mouse myoblast cell, was characterized using this method.
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