Abstract
PRESENTLY used in vitro test systems for drug and toxicity investigations lack the complexity of the liver and reduce test systems solely to hepatocytes or random co-cultures with non-parenchymal cells. Unfortunately, hepatocytes rapidly lose their typical morphology and the expression of metabolizing enzymes, which leads to cell phenotypes that differ from those found in the human physiology. This unstable phenotype is one of the main reasons for the failure to correctly predict drug-induced liver toxicity.
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