Abstract
The fabrication of a deep (28 μm, aspect ratio 3:1) cyclo-olefin polymer (COP) microcolumn and separation of varying polarity chemicals is described. A silicon master is first fabricated and utilized to hot-emboss the COP foil, which is subsequently sealed with thermal bonding. The microcolumn material (COP) is used unmodified, taking advantage of the hydrophobic properties of the COP which simplify the fabrication process of the microcolumn. Then, evaluation of the COP microcolumn ability for reversed phase chromatographic separations is performed and finally a successful separation of a mixture of four chemicals is demonstrated using a portable microfluidic set up and large injection volumes (100 nl) without an on-chip injector.
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