Abstract
Calcium phosphates (CaP) represent an impressive kind of biomedical material due to their excellent biocompatibility, bioactivity, and biodegradability. Their morphology and structure highly influence their properties and applications. Whilst great progress has been made in research on biomedical materials, there is still a need to develop a method that can rapidly synthesize and screen micro/nanosized biomedical materials. Here, we utilized a microarray screening platform that could provide the high-throughput synthesis of biomedical materials and screen the vital reaction conditions. With this screening platform, 9 × 9 sets of parallel experiments could be conducted simultaneously with one- or two-dimensions of key reaction condition gradients. We used this platform to establish a one-dimensional gradient of the pH and citrate concentration and a two-dimensional gradient of both the Ca/P ratio and pH to synthesize CaP particles with various morphologies. This screening platform also shows the potential to be extended to other reaction systems for rapid high-throughput screening.
Highlights
Calcium phosphates (CaP) are of special interest in tissue engineering because they are similar to the major inorganic component of natural hard tissues, such as bones and teeth, and their excellent bioactivity, biocompatibility, and osteoconductivity make them promising biomedical materials [1]
By forming a hydrogel block with two grooves (Step 1) and adding different concentrations of reagent A into the grooves respectively, reagent A was transported through the hydrogel block due to the concentration difference and a concentration gradient of reagent A was generated in the hydrogel block and in the half perforated polydimethylsiloxane (PDMS) chip (1), which was placed beneath the hydrogel block (Step 2)
Since both PDMS chips were fabricated with the same polymethyl methacrylate (PMMA) mold, the holes in the different chips could be matched perfectly and thereby formed an array of sealed microreactors
Summary
Calcium phosphates (CaP) are of special interest in tissue engineering because they are similar to the major inorganic component of natural hard tissues, such as bones and teeth, and their excellent bioactivity, biocompatibility, and osteoconductivity make them promising biomedical materials [1]. They have been widely studied for bone regenerative applications, such as bone cements, scaffolds, implants, and alloy coatings [2]. Such research methods usually require a long research and development cycle and are accompanied by a waste of resources, so a better and more effective research mode is desired [10,11]
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