Abstract
SummaryA spectrophotofluorometric method for determination of plasma salicylates is described in which a dextrangel (Sephadex) filtration system is used instead of solvent extraction or protein precipitation for separation of non-protein-bound salicylate from plasma protein. This method permits rapid estimation of binding of drug to protein in addition to estimation of free, acetyl and total salicylate. At physiological pH very little salicylate is bound to the protein in dog plasma (<10%) whereas in the human, as much as 40-50% of the salicylate is bound at plasma levels of 20-25 mg%.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
