Abstract
An efficient methodological approach for the synthesis of a novel series of 4-aryl-8-arylidene-2-cyanoimino-1,2,3,4,5,6,7,8-octahydroquinazolines (aryl-CIOHQs) was presented via one-pot four-component reaction of cyclohexanone, two-folds of various aromatic aldehydes and cyanoguanidine in the presence of sodium ethoxide as basic catalyst. The same target products (aryl-CIOHQs) were also reproduced in good yields using an ordinary method via two-component reaction of 2,6-diarylidinecyclohexanone derivatives with cyanoguanidine in the same condition.
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