A method of measuring rate and degree of absorption of antigens: As applied to effects of certain drugs, menstrua, and modes of administration

Abstract

A method has been presented for demonstrating quantitatively the absorption rate and tide of injected antigens. Subject to the experimental conditions and limitations of this method a number of significant observations of clinical import are noted. Glycerinated extracts are not more slowly absorbed than aqueous extracts. Intracutaneous administration appears to result usually in more rapid absorption than subcutaneous. Ephedrine administered orally preceding antigen administration causes only a slight delay in absorption and has no marked effect on the prolongation of the absorption curve. Adrenalin, either administered with the antigen or separately, has a marked effect in delaying the onset of appreciable absorption and has a more moderate effect in diminishing the height of the antigen concentration in the blood.