Abstract
ABOUT four years ago I observed the effect of a concentrated solution of quinine and urea which was injected into an angioma of the tongue, that had been repeatedly cauterized with carbon dioxide snow without reducing its size or vascularity. Injections of a SO per cent, solution caused the tumor to disappear completely; the tongue assumed its normal size and color and there has been no return of the condition since. Shortly after treating the angioma, I used the quinine and urea injection in a severe case of toxic exophthalmic goiter. The patient was too ill to stand even the slight operation involved in Hgating the superior thyroid arteries; the improvement following the injection was more decided than I have ever seen following ligation. Since my preliminary report, I have used quinine and urea injections in over one hundred cases of goiter with no unpleasant effects. I recommend the method only to relieve hyperthyroidism and not to remove the goiter. It is often true that in small toxic and atoxic goiter, the inflammatory reaction following the injection is sufficient to cause the disappearance of the tumor; but the process is slow, usually covering several months, and when used for this purpose alone, the results are liable to be disappointing.
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