A method for measuring the volume of transdermally extracted interstitial fluid by a three-electrode skin resistance sensor.

Dachao Li,Kexin Xu,Wenshuai Liang,Yue Sun,Haixia Yu,Guoqing Li,Ridong Wang

doi:10.3390/s140407084

Abstract

It is difficult to accurately measure the volume of transdermally extracted interstitial fluid (ISF), which is important for improving blood glucose prediction accuracy. Skin resistance, which is a good indicator of skin permeability, can be used to determine the volume of extracted ISF. However, it is a challenge to realize in vivo longitudinal skin resistance measurements of microareas. In this study, a three-electrode sensor was presented for measuring single-point skin resistance in vivo, and a method for determining the volume of transdermally extracted ISF using this sensor was proposed. Skin resistance was measured under static and dynamic conditions. The correlation between the skin resistance and the permeation rate of transdermally extracted ISF was proven. The volume of transdermally extracted ISF was determined using skin resistance. Factors affecting the volume prediction accuracy of transdermally extracted ISF were discussed. This method is expected to improve the accuracy of blood glucose prediction, and is of great significance for the clinical application of minimally invasive blood glucose measurement.

Highlights

Invasive blood glucose measurements based on the transdermal extraction and analysis of interstitial fluid (ISF) has gained the attention of researchers
We present a three-electrode sensor to non-invasively realize in vivo longitudinal skin resistance measurements with high accuracy, which eliminates the interference of lateral skin resistance
A skin resistance curve was drawn according to the average values of the skin resistance obtained from several ISF extractions

Summary

Introduction

Invasive blood glucose measurements based on the transdermal extraction and analysis of interstitial fluid (ISF) has gained the attention of researchers. This method determines the blood glucose level based on monitoring the glucose concentration in ISF because a close relation exists between the glucose concentration of the ISF and that of blood [1]. The advantages of this method include that this method is painless and that continuous monitoring can be realized [2]. Our research group proposed a method using ultrasound and vacuum to overcome the drawbacks of the GlucoWatch G2 Biographer device

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Conclusion