Abstract
In this work, we present a novel method for measuring solubility designed specifically for multi-component supercritical fluids. The method is based on an online hyphenation of supercritical antisolvent precipitation and subsequent supercritical fluid chromatography. A concentrated solution of a target substance in an organic solvent is contacted with supercritical CO2 or other fluid in a precipitation chamber which leads to partial precipitation of the compound. A small portion of the outlet stream is repeatedly injected into a supercritical fluid chromatography, and concentration measurement is performed using a pre-defined calibration. Solubility of aspirin as a model object in CO2-methanol, CO2-ethanol and CO2-acetone was measured using this method, results are in good agreement with available literary data. The method allows gaining several data points per day which is much faster than the majority of existing methods for solubility measurement in multi-component supercritical fluids.
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