Abstract

The ionic current properties of a neuron play a fundamental role for generating the voltage responses such as post synaptic potential and action potential. The voltage- and time-dependent characteristics of each ionic current can be measured by applying voltage clamp techniques which lead to the precise measurement of the membrane ionic currents underlying the voltage response. From these measurements it is possible to obtain the exact mathematical descriptions of the ionic current in response to electrical and chemical stimuli similar to Hodgkin-Huxley equations[1]. The ionic current model provides a basis for understanding how the individual ionic current flows during the response and/or predicts the blocking effect of a particular ionic channel.

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