Abstract

Medical images are an important source of information for both diagnosing and treating diseases. In many cases, the images produced by a Positron Emission Tomography (PET) scan are used to assess the effectiveness of a particular treatment. This paper presents a method for whole-body PET image denoising using a spatially-guided non-local means filter. The proposed method starts with clustering the images into regions. To estimate the noise, a Bayesian with automatic settings of the parameters was used. Then, only patches that belong to regions were collected and processed. The performance was compared to two methods; Gaussian and conventional Non-Local Means (NLM). The Jaszczak phantom and PET/ Computed Tomography (CT) for whole-body were involved in the benchmarking. The obtained results showed that in the Jaszczak phantom, the Signal-to-Noise Ratio (SNR) was significantly improved. Additionally, the proposed method improved the contrast and SNR compared to conventional NLM and Gaussian. Finally, the proposed method, in clinical whole-body PET, can be considered as another way of the post-reconstruction filter.

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