Abstract
A method of characterising serum fibrinogen and fibrin degradation products is described. A commercial antiserum to human fibrinogen was covalently bound to agarose beads and used to precipitate fibrinogen related antigens from in vitro plasmin digests and from serum. The degradation products were then examined by electrophoresis on polyacrylamide gels in the presence of dodecyl sulphate. Using this method solutions containing greater than 30μgrams of FDP may be characterised, and discrimination between in vitro produced fibrin and fibrinogen degradation products is possible. The application of the method is illustrated by the characterisation of serum FDP of a patient undergoing intermittent plasminogen/streptokinase therapy for deep vein thrombosis.
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