Abstract
AbstractA novel and efficient L‐proline catalyzed Michael reaction of several 4‐aryl/heteroaryl‐substituted cyclic sulfamidate imines with a variety of β‐styryl/aryl/alkyl‐substituted acroleins, followed by in situ elimination‐iminocyclization‐dehydration sequence process in the presence of DABCO as a base is reported for the first time. By this unconventional one‐pot sequential protocol, a number of 2‐aryl/heteroaryl‐4‐styrylpyridines and 2,4‐diarylpyridines have been prepared in good to high yields under metal‐free conditions. Besides, the synthesized 4‐styrylpyridine derivatives were also further utilized for the synthesis of commercially as well as pharmaceutically important 2‐arylisonicotinic acids.
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