Abstract
BackgroundAsthma, one of the most common chronic respiratory disorders, is associated with the hyper-activation of the T-cell subset of adaptive immunity. The gut microbiota may be involved in the development of asthma through the production of short-chain fatty acids (SCFAs), exhibiting modulatory effects on Th. So, we performed a metagenome-wide association study (MWAS) of the fecal microbiota from individuals with asthma and healthy controls. And that was the first case to resolve the relationship between asthma and microbiome among UK adults.ResultsThe microbiota of the individuals with asthma consisted of fewer microbial entities than the microbiota of healthy individuals. Faecalibacterium prausnitzii, Sutterella wadsworthensis and Bacteroides stercoris were depleted in cases, whereas Clostridiums with Eggerthella lenta were over-represented in individuals with asthma. Functional analysis shows that the SCFAs might be altered in the microbiota of asthma patients.ConclusionIn all, the adult human gut microbiome of asthma patients is clearly different from healthy controls. The functional and taxa results showed that the change of asthma patients might related to SCFAs.
Highlights
Asthma, one of the most common chronic respiratory disorders, is associated with the hyper-activation of the T-cell subset of adaptive immunity
We identify meta-genomic species (MGSs) [12] characteristic of asthma, and the differentially enriched Gut metabolic modules (GMMs) [13] between asthma and control samples, which revealed an association of altered short chain fatty acid metabolism with asthma
Patients diagnosed with asthma was associated with an alteration of the global microbiota composition (Additional file 2: Table S2), along with a couple of lifestyle factors, Body Mass Index (BMI)and ages, which show great difference in PERMANOVA (Additional file 2: Table S2), but not significant between asthma and control samples (Fig. 1c, d)
Summary
One of the most common chronic respiratory disorders, is associated with the hyper-activation of the T-cell subset of adaptive immunity. The gut microbiota may be involved in the development of asthma through the production of short-chain fatty acids (SCFAs), exhibiting modulatory effects on Th. So, we performed a metagenomewide association study (MWAS) of the fecal microbiota from individuals with asthma and healthy controls. The gut microbiota influences metabolic and immune homeostasis [4, 5]. This symbiotic relationship is related to diverse host physiological functions [6]. The microbiome possibly influences the T-cell populations through the microbe-derived short-chain fatty acids (SCFAs), which can regulate T cell activity and further affect asthma [8]. As the metabolic balance of SCFAs depends on the symbiosis of microbiota, an impaired gut micro-ecosystem might be
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