A Meta-Analysis of Risk Factors for Liver Cirrhosis Combined with Upper Gastrointestinal Bleeding in China

Abstract

In order to systematically evaluate the risk factors for liver cirrhosis complicated with upper gastrointestinal bleeding in China, we searched CNKI, Wanfang Digital Journals Full-text Database (Wanfang), Weipu Journal Resource Integration Service Platform(VIP) and PubMed database on risk factors for liver cirrhosis combined with upper gastrointestinal bleeding in China, Newcastle-Ottawa Scale(NOS) used the most comprehensive data collection based on relevant case-control trials to evaluate the quality of the extracted literature combined with inclusion and exclusion criteria. Studies with a score of ≥ 7 were included and meta-analysed using RevMan 5.4. Finally, twenty-one articles met the inclusion criteria, the cumulative number of cases and controls were 2222 and 2785 cases. We can come to the conclusion that Spleen, gastric varices, esophageal varices, PT (prothrombin time), ascites, left gastric vein diameter, liver function child grade C, esophageal varices, liver cirrhosis, portal vein diameter, and alcohol consumptionIt is an independent risk factor for liver cirrhosis combined with upper gastrointestinal bleeding in China, and the control of the above factors can effectively improve the risk of patients with liver cirrhosis and upper gastrointestinal bleeding in China.