A Meta-Analysis on the Relationship of the PON Genes and Alzheimer Disease.

Abstract

This study aimed to evaluate the association of the paraoxonase (PON) gene variants and Alzheimer disease (AD) using meta-analysis. Relevant studies were identified by searching English and Chinese databases extensively. Allele and genotype frequencies for each included study were extracted. Newcastle-Ottawa Scale (NOS) was employed to assess the quality of included studies. The odds ratio (OR) with 95% confidence interval (95% CI) was calculated using a random-effects or fixed-effects model. A Q statistic was used to evaluate homogeneity, and Egger test and funnel plot were used to assess publication bias. A total of 15 studies (involving 5 polymorphisms) were included and identified for the current meta-analysis. The NOS scores ranged from 7 to 8, meaning good quality of studies. It was found that the SS genotype of PON2 S311C polymorphism had an significant association with AD in the studied population (OR = 0.82, 95% CI: 0.68-0.99, P = .04), and the A allele of PON1 rs705379 polymorphism was positively related to AD in Caucasian population (OR = 1.21, 95% CI: 1.05-1.39, P = .009) as well as the GG genotype decreased AD risk significantly in Caucasians (OR = 0.7, 95% CI: 0.56-0.88, P = .002). However, there was no significant relationship between other 3 genetic variants of PON genes (L55 M, Q192 R, and -161C/T of PON1 gene) and AD. Existing evidence indicates that the S311C polymorphism (SS genotype) and the rs705379 (the A allele and GG genotype) are associated with risk of AD in studied population. Future studies with larger sample sizes will be necessary to confirm the present results.