A Meta-analysis on relationship between Lp-PLA2 and different types of coronary heart disease

Abstract

Objective The relationship between serum lipoprotein-associated phospholipase A2(Lp-PLA2) and different types of coronary heart disease (CHD) was studied. Methods Literatures concerning CHD and Lp-PLA2 published from January 2004 to December 2013 in “Wan fang”,“CNKI”,PubMed and Science Citation Index Expanded（SCIE）/Social Sciences Citation Index （SSCI）/Arts and Humanities Citation Index（A&HCI） database were retrievaled,and then relevant data were extracted.RevMan5.1 statistical software was used for processing and analysis. Results A total of 8 literatures involving 1 292 subjects were included.Meta-analysis showed that the levels of serum Lp-PLA2 in the patients with stable angina (SA),unstable angina (UA) or acute myocardial infarction (AMI) were significantly higher than those of normal controls,respectively ［SMD(95%CI) were 2.46(1.20,3.71),2.68(1.47，3.89), and 2.57(1.50,3.65), all P=0.000］.Serum Lp-PLA2 level in patients with UA or AMI was higher than that in patients with SA,respectively［SMD=0.78，95%CI（0.28,1.28），P=0.002］,［SMD= 1.12，95%CI（0.72,1.51），P=0.000］；Serum level of Lp-PLA2 in patients with AMI was also higher than that in patients with UA［SMD= 0.58，95%CI（0.29,0.86），P=0.000］. Conclusion The study demonstrated that increased serum Lp-PLA2 level is significantly associated with the severity of CHD.（Chin J Lab Med,2014,37:527-530） Key words: Coronary disease; Meta-analysis