A meta-analysis of the impact of a phosphate-specific diet on serum phosphate levels in people receiving hemodialysis

Zhumeei Giong,Nai Lie

doi:10.61466/ijcmr2040005

Abstract

Background We performed a meta-analysis to evaluate the influence of a phosphate-specific intake on serum phosphate levels in hemodialysis subjects. Methods A systematic literature search up to November 2021 was done and 14 studies included 1284 hemodialysis subjects at the start of the study; 671 of them were provided with phosphate-specific intake, and 613 were control. We calculated the mean difference (MD) with 95% confidence intervals (CIs) to evaluate the influence of phosphate-specific intake on serum phosphate levels in hemodialysis subjects by the contentious method with a random or fixed-influence model. <span style="font-size: 10.0pt; font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-fareast-font-family: Calibri; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;">Results Phosphate-specific intake <span style="font-size: 10.0pt; font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-fareast-font-family: Calibri; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;">had significantly better serum phosphate levels change (MD, -0.66; 95% CI, -0.95- -0.36, p&lt;0.001) with moderate heterogeneity (I2 = 71%) compared to control in hemodialysis subjects Conclusions Phosphate-specific intake <span style="font-size: 10.0pt; font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-fareast-font-family: Calibri; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;">had significantly lower serum phosphate levels change compared to control in hemodialysis subjects. Further studies are required.

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