Abstract
This meta-analysis of published randomized clinical trials (RCTs) compared the efficacy of granisetron 0.1 mg versus ≥ 1.0 mg for prevention of postoperative nausea and vomiting (PONV). Efficacy data (proportion of patients without PONV or requiring rescue medication) were extracted and stratified by the postoperative period (i.e., early, late, and overall). Meta-analytic techniques were used to integrate findings and estimate pooled efficacy. Ten RCTs met inclusion criteria, but only 2 directly compared granisetron 0.1 mg versus 1.0 mg, which was insufficient for meta-analysis, necessitating indirect comparisons between pairwise sets of granisetron 0.1 mg and granisetron 1.0 mg with common comparators: placebo and granisetron dose levels > 1.0 mg. Granisetron 0.1 mg appears to be at least as effective as granisetron 1.0 mg during the early and overall postoperative periods. There were insufficient data for meta-analysis of any outcomes during the late postoperative period. CONFLICT OF INTEREST DISCLOSURE The author received in the past financial support (Independent Investigator Grant) from Roche Pharmaceuticals (maker of Kytril-granisetron).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
