Abstract
Serum levels of ischaemia-modified albumin (IMA) have been studied as a novel and simple measure of oxidative stress (OXS) in different thyroid pathologies. However, results of available studies in the literature were not consistent. This meta-analysis was attempted to quantify the overall effect size for serum IMA levels in human hypothyroidism (HT) and hyperthyroidism (HYT) and to study its associations with the thyroid profile. Databases of PubMed/Medline, EMBASE, Google Scholar, Web of Science and Science Direct were searched for articles. Data on serum IMA levels in HT, HYT patients and euthyroid controls were extracted to compute standardized mean differences (SMD) by the random-effects model. The associations between IMA and thyroid profile were computed by the meta-analysis of correlation coefficients. IMA levels in HT patients (SMD=1.12; Z=2.76; P=0.006) and HYT patients (SMD=1.64; Z=2.57; P=0.01) were significantly higher than in euthyroid controls and the thyroid treatment showed a favourble effect on serum IMA levels. There were strong and significant correlations between IMA and hormonal status in HT and HYT groups. This meta-analysis showing increased IMA level in both HT and HYT patients and its association with thyroid profile suggests that serum IMA could be used as a simple measure of increased OXS in thyroid dysfunction.
Highlights
Thyroid disorders are majorly studied under two types: hypothyroidism (HT) and hyperthyroidism (HYT)
Using all available data to compare serum ischaemia-modified albumin (IMA) levels in HYT patients compared with healthy controls, we found a significant difference between these two groups
In HYT patients, the increased serum IMA correlated positively with FT4 and FT3. This is the first time that a meta-analysis examines IMA in human HT and HYT. This meta-analysis suggested that IMA levels in serum were higher in both HT and HYT patients than healthy euthyroid controls, which indicated an increased oxidative stress (OXS) status
Summary
Thyroid disorders are majorly studied under two types: hypothyroidism (HT) and hyperthyroidism (HYT). HT is characterized by excess thyrotropin (TSH) and underproduction of thyroid hormones, whereas HYT is due to low TSH and overproduction of thyroid hormones. Both of these disorders can exist in clinical and subclinical states. OXS causes modification of the normal HSA at its metal-binding sites, decreasing its binding capacity for metals such as cobalt. This modified form of albumin is known as ischaemia-modified albumin (IMA) and its formation was first detected and c 2017 The Author(s).
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