Abstract
Pancreatic neuroendocrine neoplasms (pNENs) are a group of clinically rare and heterogeneous diseases of the pancreas. However, the prognostic factors for this disease in patients still remain controversial. The purpose of our study is to evaluate the predictive roles of those prognostic factors for pNENs. All related articles published until Sep 17, 2017 were identified via PubMed, EMBASE, Web of Science, Ovid and the Cochrane Library. Studies that examined the prognostic factors of pNENs were enrolled. 17 articles (2822 patients) were finally included in this study. The pooled data suggested that patients with positive surgical resection margin and lymph node, advanced G stage and TMN stage, organ metastasis, vascular invasion and the necrosis of specimens had a decreased overall survival for pNENs. Similarly, patients with functional tumors might have a poor prognosis. However, age, gender, surgical type and size of tumor could not be regarded as prognostic factors for pNENs. Our analytic data demonstrated that surgical resection margin, G stage, TMN stage, lymph node, metastasis, vascular invasion and the necrosis could be prognostic factors for pNENs. Our study may assist doctors to screen patients with different prognosis more efficiently during follow-up and select appropriate treatment measures.
Highlights
While the percentage of PNENs in all pancreatic tumors is only 1% to 2%, the incidence has increased apparently in the past few years[4,5]
As reported in some studies[7,8,9,10], a large number of factors including older age, large tumor size, positive resection margin, advanced G stage and TMN stage, vascular invasion, organ metastasis could indicate a poor prognosis of Pancreatic neuroendocrine neoplasms (pNENs)
There is still no set of standard rules to determine the prognosis of patients
Summary
While the percentage of PNENs in all pancreatic tumors is only 1% to 2%, the incidence has increased apparently in the past few years[4,5]. The interest on pancreatic neuroendocrine neoplasms (pNENs) has grown[6]. The prognosis of pNENs in the population varies. As reported in some studies[7,8,9,10], a large number of factors including older age, large tumor size, positive resection margin, advanced G stage and TMN stage, vascular invasion, organ metastasis could indicate a poor prognosis of pNENs. In contrast, people with function tumors, low tumor marks might have a better outcome. Effective prognostic factors are in great need. We performed this meta-analysis to further evaluate the predictive roles of these prognostic factors for pNENs
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