Abstract
The genetic variants of Mannose-Binding Lectin, a vital component of innate immunity have been studied with acute/recurrent vaginal infections ((R)VVI) and presented inconclusive findings. Therefore, a systematic review and meta-analysis of published data were conducted to assess the possible role of these variations in (R)VVI. A comprehensive search was made using PubMed, Web of Science and Google scholar till June 18, 2019. A total of 12 studies met the specified criteria and were included in the analysis. Different comparisons were made on the basis of the outcome of interest that resulted in the filtering of studies for the pooled analysis to find an association using the standard genetic models. Odds ratio (OR) with 95% confidence interval (CI) was chosen as the effect measure for the data synthesis. The trim and fill technique was applied to adjust the publication bias. The meta-analysis revealed the significant association (p < 0.05) of rs1800450 polymorphism with RVVI risk (OR ≥ 3.5) in all the genetic models. The subgroup analysis identified the same association in Caucasian and Mixed ethnicity. Quantitative synthesis based on RVVC showed>3.5 fold risk of disease development accredited to rs1800450. A combined evaluation of Exon1 variants showed no association with (R)VVI. This meta-analysis suggests rs1800450 polymorphism as a genetic predisposing factor for RVVI, but to reinforce, further studies with a larger sample size are warranted.
Highlights
By considering the importance of gene in view, studies have examined the possible association between MBL2 polymorphisms in susceptibility to (R)VVI in different populations[8,9,10,16,17,18,19,20,21,22,23,24]
The genotype distributions in controls were in accordance with Hardy-Weinberg equilibrium (HWE) in all the studies except two[17,22]
Moderator and Subgroup analysis: Further for the better interpretation of quantitative synthesis, we studied the effect of ethnicity on effect size (ES) and variability among the included studies (Table S5)
Summary
By considering the importance of gene in view, studies have examined the possible association between MBL2 polymorphisms in susceptibility to (R)VVI in different populations[8,9,10,16,17,18,19,20,21,22,23,24]. Owing to ethnic diversity and underpowered study design, the conclusions provided by these reports are still controversial, demanding further in-depth investigation to establish the relationship between the two. In order to provide scientifically rigorous summarised information, a systematic review of hitherto literary evidences and the quantitative synthesis of data obtained, were performed in this study by applying a well recognised statistical method—a meta-analysis, making the current investigation a primary approach towards it
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