Abstract
ObjectiveIt remains inconclusive whether Hashimoto’s thyroiditis (HT) predisposes patients to the development of papillary thyroid carcinoma (PTC). We conducted a meta-analysis of the available data to address this question.ResultsTwenty-seven eligible studies were selected, including 18 archival thyroidectomy studies, 6 fine-needle aspiration (FNA) studies, and 3 selective FNA or thyroidectomy studies. A total of 76,281 patients, including 12,476 cases of thyroid cancer, were included in these studies. The mean rate of PTC among patients with HT ranged from 1.12% (selective FNA or thyroidectomy studies) to 40.11% (thyroidectomy studies). All three types of studies supported the correlation between HT and PTC. The overall pooled odds ratio (OR) of the PTC risk for HT (HT versus non-HT) was 2.12 (95% confidence interval [CI]: 1.78-2.52).MethodsWe searched all relevant published studies using the citation databases PubMed and Embase. The ORs and corresponding 95% CIs were calculated by the random-effects model for the association between HT and PTC.ConclusionsOur meta-analysis confirmed that HT predisposed patients to the development of PTC.
Highlights
Hashimoto’s thyroiditis (HT) is the most common autoimmune thyroid disease which causes the immune system to attack and destroy the thyroid gland [1]
The mean rate of Papillary thyroid carcinoma (PTC) among patients with HT ranged from 1.12% to 40.11%
Our meta-analysis confirmed that HT predisposed patients to the development of PTC
Summary
Hashimoto’s thyroiditis (HT) (or chronic lymphocytic thyroiditis) is the most common autoimmune thyroid disease which causes the immune system to attack and destroy the thyroid gland [1]. Dailey et al were the first to propose an association between HT and PTC in 1955, linking chronic inflammation to neoplastic changes [2]. Some studies have revealed a higher risk of PTC in patients with HT [3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20], while others did not demonstrate the increased risk [21,22,23]. Lee et al published a metaanalysis and found that PTC is significantly associated with pathologically confirmed HT [24]. Because inconsistent results have been reported regarding the association between HT and PTC risk, and because many other related studies have been published in recent years, we performed a comprehensive meta-analysis to investigate the possible associations of HT and PTC
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