A meta-analysis examining the impact of antibiotic prophylaxis on surgical site wound infection during third molar surgery

Zhang Weang

doi:10.61466/ijcmr2040004

Abstract

<a name="_Hlk120288420"></a>Backgrounds The meta-analysis aims to estimate the effect of antibiotic prophylaxis (AP) on surgical site wound infection (SSWI) in third molar surgery (TMS). Methods Examinations comparing AP to placebo for TMS were utilized in the meta-analysis from various languages that met the inclusion criteria. Using dichotomous random or fixed effect models, the results of these investigations were examined, and the Odd Ratio (OR) with 95% confidence intervals was computed (CIs). 18 examinations from 2001 to 2023 were recruited for the current analysis including 4063 personals with TMS who were in the utilized examinations' starting point. Results AP had significantly lower SSWI (OR, 0.46; 95% CI, 0.33-0.65, p&lt;0.001) with no heterogeneity (I2 = 1%) compared to placebo in personals with TMS. Conclusions The examined data revealed that AP had significantly lower SSWI compared to placebo in personals with TMS. Nevertheless, caution should be exercised while interacting with its values since examinations were performed by different surgeons with different skills on different types of personals and the low sample size of numerous of the examinations selected for the meta-analysis.

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