A meta-analysis: Does vitamin D play a promising role in sleep disorders?

Shoumeng Yan,Hantong Zhao,Zhenwei Tian,Bo Li,Yingan Pan,Yinpei Guo,Weiwei Cui,Nan Yao,Changcong Wang,Han Wang

doi:10.1002/fsn3.1867

Abstract

BackgroundSleep disorders, one of the most common problems in the general population, have been related to a series of harmful health consequences. Vitamin D appears to be associated with sleep disorders. However, the difference in vitamin D levels between sleep disorder subjects and people without a sleep disorder is unclear. Simultaneously, the influence of vitamin D replenishment on sleep disorders remains controversial.MethodsPubMed, MEDLINE, Web of Science, and Cochrane Library were searched for literatures published until October 2019. Using a random effects model, a meta‐analysis was conducted to calculate the standard mean difference to evaluate the difference in vitamin D concentrations between sleep disorder subjects and normal people and the efficacy of vitamin D supplementation on sleep disorders.ResultsOur study found that the serum vitamin D levels in the sleep disorder subjects were lower than that in the normal people (SMD = −0.75 ng/ml, 95% CI = −0.93, −0.57 ng/ml). Moreover, the Pittsburgh Sleep Quality Index (PSQI)in the subjects with vitamin D supplementation was lower than that in the controls (SMD = −0.45, 95% CI = −0.76, −0.13).ConclusionsVitamin D could play a promising role in sleep disorders. More data are required to confirm the efficacy of vitamin D supplementation for improving sleep disorders.

Highlights

Sleep is a complex physiological state that involves a period of intense metabolic activity.Shortening or interrupting sleep may cause some nonspecific symptoms, including general weakness, physical discomfort, cognitive, and emotional impairment (McCarty, Chesson, Jain, & Marino, 2014)
The following terms were used for the literature search: vitamin D, cholecalciferol, ergocalciferol, sleep quality, sleep disorders, and Pittsburgh Sleep Quality Index (PSQI)
We considered the combination of east and Vitamin D supplementation compared with no vitamin D intervention for improving sleep quality

Summary

| INTRODUCTION

Sleep is a complex physiological state that involves a period of intense metabolic activity (de Oliveira, Hirotsu, Tufik, & Andersen, 2017). Shortening or interrupting sleep may cause some nonspecific symptoms, including general weakness, physical discomfort, cognitive, and emotional impairment (McCarty, Chesson, Jain, & Marino, 2014). Most sleep disorders, such as sleep apnea, periodic. Previous studies have shown that abnormally low concentrations of vitamin D are general in patients seeking sleep medication and may be the causes or contributors to sleep disorder (McCarty et al, 2014). A meta-analysis was performed evaluating the difference in vitamin D between sleep disorder people and normal people. The meta-analysis evaluated all related randomized control trials (RCTs) with a focus on the influence of vitamin D supplementation on sleep disorders

| METHODS

Assay Method

| DISCUSSION

Findings

| CONCLUSIONS