Abstract
BackgroundThis study aimed to compare the outcomes of patients undergoing anatomical resection (AR) versus non-anatomical resection (NAR) for hepatocellular carcinoma (HCC) from the published comparative studies within the literatures. MethodsA meta-analysis of studies published from 2001 to 2010 were conducted using RevMan 5.0. Measured outcomes were morbidity, mortality, recurrence and 5 year overall (OS) and disease free (DFS) survival. ResultsSeventeen observational studies involving 3129 patients were analyzed: 1626 (52%) in AR group and 1503 (48%) in NAR group. The 5-year OS (RR, 1.18; 95% CI, 1.03–1.36; P = 0.018) and DFS (RR, 1.56; 95% CI, 1.23–1.97; P < 0.001) were significantly greater in the AR group than the NAR group, while the overall recurrence was significantly lower (RR, 0.84; 95% CI, 0.75–0.94; P < 0.001). There were no significant differences in mortality (RR, 1.00; 95% CI, 0.80–1.25; P = 0.980) or morbidity (OR, 0.97; 95% CI, 0.48–1.99; P = 0.943) between the AR and NAR groups. ConclusionAR for HCC is superior to NAR considering its higher 5-year OS and DFS rates and lower overall recurrence rate. Heterogeneity detection within the analysis suggests these results should be interpreted with caution and further well designed studies are required to address this issue.
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