Abstract
For different populations, the association studies between the beta-2 adrenergic receptor (ADRB2) Arg16Gly mutation and asthma are conflict. This study was designated to evaluate ADRB2 Arg16Gly polymorphism and asthma in Chinese population. Systemic assessment was performed based on the data from PubMed, Embase, Web of Science, the Cochrane Library, and Chinese National Knowledge Infrastructure (CNKI) up to January 2019. Odds ratios (ORs) with their 95% confidence intervals (95% CIs) were calculated using STATA software. This meta-analysis included 6143 asthma patients and 5919 healthy persons from 34 studies. Overall, ADRB2 Arg16Gly polymorphism showed no significant influence on asthma in China. However, subgroup analyses according to geographic areas, age group and HWE in controls, only found a borderline significant effect for southern Chinese under the homozygotes genetic model (OR = 0.82, 95%CI = 0.68-1.00, P = 0.046). This meta-analysis suggests that ADRB2 Arg16Gly polymorphism is not be related to the development of asthma in China.
Highlights
Asthma is a kind of allergic disease of the respiratory tract, and has become a global public health problem in recent years (To et al, 2012).The prevalence of asthma is 0.2-21.0% wordwide, which is still increased, especially in developing countries such as China (To et al, 2012; Pearce et al, 2007; Yangzong et al, 2012)
Practical Application: This meta-analysis proves that ADRB2 Arg16Gly polymorphism is not related to in development of asthma in China
6143 asthma cases and 5919 healthy controls for assessing the relation between ADRB2 Arg16Gly polymorphism and asthma risk among Chinese were included in this analysis study (Table 1)
Summary
Asthma is a kind of allergic disease of the respiratory tract, and has become a global public health problem in recent years (To et al, 2012).The prevalence of asthma is 0.2-21.0% wordwide, which is still increased, especially in developing countries such as China (To et al, 2012; Pearce et al, 2007; Yangzong et al, 2012). Numerous reports demonstrated that multiple genetic variations are involved in asthma. Among these genetic variations, the polymorphisms in beta-2 adrenergic receptor (ADRB2) have been most evaluated in asthma. Single nucleotide polymorphisms of ADRB2 in the coding gene region including Arg16Gly (A46G, rs1042713), Gln27Glu (C79G, rs1042714), Thr164Ile (C491T, rs1800888) and Arg19Cys (T-47C, rs1042711). Have proven the influence of ADRB2 activation on the small airways, suggesting the effective therapy of ADRB2 agonists in asthma The mutation of the Arg16Gly located at the ADRB2 gene has been extensively examined in studies on ADRB2 polymorphisms in asthma.
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