A meta-analysis about the relation of polymorphism at the sites + 49 of cytotoxic T-lymphocyte associated antigen 4 gene with the susceptibility of Graves' disease in Asian population

Abstract

Objective To review the quantitative relationship of polymorphism at the sites +49 of cytotoxic T-lymphocyte associated antigen 4 gene with the susceptibility of Graves' disease(GD) in Asian population.Methods The Medline,PubMed,Embase,Web of Science,and Chinese Biomedical Literature Database on disc (CBM disc) databases were searched and used in meta-analysis to analyze the data in the articles collected.Results This analysis included a total of 24 papers,and GD patients and healthy population control group were composed of 4 832 cases and 5 643 subjects respectively.This paper revealed that in the general population,the Chinese people and the Japanese crowd,all the genetic models (allele,co-dominant model,dominant model,recessive model) were statistically significant,indicating that CTLA-4 +49 A allele could reduce the risk of GD.Conclusions The CTLA-4 +49 G→A mutation allele may serve as a factor in reducing the risk of GD susceptibility in Asian population. Key words: Graves' disease; Cytotoxic T-lymphocyte associated antigen 4 gene; Polymorphisms; meta-analysis