A mesoporous silver-doped TiO2-SnO2 nanocomposite on g-C3N4 nanosheets and decorated with a hierarchicalcore-shell metal-organic framework for simultaneous voltammetric determination of ascorbic acid, dopamine and uric acid.

Abstract

An electrochemical sensor is described for the simultaneous voltammetric determination of ascorbic acid (AA), dopamine (DA), anduric acid (UA). An indium-tin oxide (ITO) electrode was modified with a hierarchical core-shell metal-organic framework and Ag-doped mesoporous metal-oxide based hybrid nanocomposites on g-C3N4 nanosheets. The morphology, structural and chemical composition of the hybrid nanocomposite was characterized using different analytical methods. The modified ITO showed superior electrocatalytic performance towards the oxidation of AA, DA and UA due to the enhanced surface area, synergistic effects and well-organized porous assembly. Figures of merit, include (a) linear responses from 0.1 to 200μM, 2.5 to 100μM and 2.5 to 625μM; (b) detection limits (at S/N= 3) of 0.02, 0.01 and 0.06μM, and (c) well separated oxidation peaks near -50, 186 and 390mV (vs. Ag/AgCl) for simultaneous sensing AA, DA and UA, respectively. The sensor was evaluated by analysing spiked serum samples and gave data with precision, with recoveries of >98%. Graphical abstractSchematic Representation of a Mesoporous Silver-doped TiO2-SnO2 Nanocomposite (h-ATS) on g-C3N4 Nanosheets and Decorated with a HierarchicalCore-Shell Metal-Organic Framework (NC@GC) Based Electrochemical Sensor for Simultaneous Voltammetric Detection of Ascorbic acid, Dopamine and Uric acid.