Abstract
Optical coherence tomography (OCT) can obtain high-resolution three-dimensional (3D) structural images of biological tissues, and spectroscopic OCT, which is one of the functional extensions of OCT, can also quantify chromophores of tissues. Due to its unique features, OCT has been increasingly used for brain imaging. To support the development of the simulation and analysis tools on which OCT-based brain imaging depends, a model of mesh-based Monte Carlo for OCT (MMC-OCT) is presented in this work to study OCT signals reflecting the structural and functional activities of brain tissue. In addition, an approach to improve the quantitative accuracy of chromophores in tissue is proposed and validated by MMC-OCT simulations. Specifically, the OCT-based brain structural imaging was first simulated to illustrate and validate the MMC-OCT strategy. We then focused on the influences of different wavelengths on the measurement of hemoglobin concentration C, oxygen saturation Y, and scattering coefficient S in brain tissue. Finally, it is proposed and verified here that the measurement accuracy of C, Y, and S can be improved by selecting appropriate wavelengths for calculation, which contributes to the experimental study of brain functional sensing.
Highlights
Applications of optical coherence tomography (OCT) in brain tissue include structural imaging and functional sensing
We analyzed the application of OCT to the fields of brain tissue structural and functional imaging using a model of mesh-based Monte Carlo for OCT (MMC-OCT)
We first verified that the MMC-OCT model used in this paper is an effective analytical tool for brain researches through simulations of structural imaging
Summary
Applications of optical coherence tomography (OCT) in brain tissue include structural imaging and functional sensing. Structural imaging includes macroscopic imaging [1,2] and angiography of the brain tissue [3]. Among them, scattering and absorption can be obtained by spectroscopic OCT [6,7], and Doppler shift can be measured by Doppler OCT [8]. This paper focuses on the applications of OCT in brain structural imaging as well as in the measurement of absorption and scattering coefficients of brain tissue. Both numerical and in vivo testbeds are useful for brain tissue imaging.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have