A mechanism underlying short-term synaptic dynamics regulated by neuromodulator based on kinetics of Ca currents

Myongkeun Oh,Farzan Nadim,Shunbing Zhao

doi:10.1186/1471-2202-10-s1-p222

Abstract

The crustacean stomatogastric nervous system (STNS) is one of the most extensively researched neural systems in studying the effects of neuromodulation. Previous studies have reported the actions of neuromodulators on intrinsic neuronal properties and synaptic strength in the STNS [2], but little is known about neuromodulatory effects on the short-term synaptic dynamics. We investigated the effect of the neuropeptide proctolin on the dynamics of the inhibitory synapse from the lateral pyloric (LP) to the pyloric dilator (PD) neuron in the crab pyloric network. Synaptic transmission between these neurons consists of spike-mediated and non-spike-mediated (graded) components. The graded component of this synapse shows short-term depression in control saline, but in the presence of proctolin, low-amplitude ( 30 mV) stimulation causes depression.

Highlights

Eighteenth Annual Computational Neuroscience Meeting: CNS*2009 Don H Johnson Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2202-10-S1-info.pdf
Previous studies have reported the actions of neuromodulators on intrinsic neuronal properties and synaptic strength in the stomatogastric nervous system (STNS) [2], but little is known about neuromodulatory effects on the short-term synaptic dynamics
We investigated the effect of the neuropeptide proctolin on the dynamics of the inhibitory synapse from the lateral pyloric (LP) to the pyloric dilator (PD) neuron in the crab pyloric network

Summary

Introduction

Eighteenth Annual Computational Neuroscience Meeting: CNS*2009 Don H Johnson Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2202-10-S1-info.pdf . Address: 1Department of Mathematical Sciences, New Jersey Institute Technology, Newark, NJ, 07102, USA and 2Department of Biological Sciences, Rutgers University, Newark, NJ, 07102, USA Email: Myongkeun Oh* - mo42@njit.edu * Corresponding author from Eighteenth Annual Computational Neuroscience Meeting: CNS*2009 Berlin, Germany.

Results

Conclusion