Abstract
ABSTRACTTo gain further insight into the mechanism of immune deposition in the skin, antigens and antibodies were administered intravenously at different times into normal guinea pigs, and the presence of immune complexes in frozen sections of skin was determined immunohistochemically, using light microscopy. Cutaneous immune deposits were found after primary injection of anti‐horseradish peroxidase antibody (IgG) followed by secondary administration of horseradish peroxidase, while no immune complexes were detected after the same injections in the reverse order. This disparity may possibly be explained by the length of time the antigen or antibody remains in the skin. Using a primary injection of bovine serum albumin (BSA), followed by secondary injection of anti‐BSA antibody, immune deposits were demonstrated in the skin. In these cases, if the initially injected antigen or antibody remained for a long time at the site of exudation, they would react with and form immune complexes with the subsequently injected antibody or antigen at the same site.
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