Abstract
Sodium salt of valproic acid (VPA) is an anticonvulsant which has been successfully used in the treatment of several types of epilepsy, particularly in petit mall. It has been shown recently that VPA induced hyperammonemia in children 2,3. In the search of the mechanism by which VPA inhibits ureagenesis and because of the analogy between some other side effects of VPA and the ketotic hyperglycinemia syndrome (hyperglycinuria 4,5,6 leucopenia 7 and thrombocytopenia 8) we have studied the in vivo and in vitro metabolic effects of VPA on the mitochondrial steps of ureagenesis in rat.
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