Abstract
A Mechanism for How Programmed Cell Death Protein 5 Promotes Apoptosis during Tumorigenesis♦: Programmed Cell Death Protein 5 Interacts with the Cytosolic Chaperonin Containing Tailless Complex Polypeptide 1 (CCT) to Regulate β-Tubulin Folding
Highlights
Programmed cell death protein 5 (PDCD5) has been proposed to put the brakes on uncontrolled cell proliferation by promoting apoptosis during tumorigenesis
Willardson at Brigham Young University describes how PDCD5 interacted with a chaperonin called Containing Tailless Complex Polypeptide 1 (CCT) and one of CCT’s substrates, -tubulin, to inhibit the folding of this key component of the cytoskeleton
The authors conclude, “On the basis of these findings, we propose that the apoptotic activity of PDCD5 may result at least in part by impairing CCT-mediated -tubulin folding.”
Summary
Programmed cell death protein 5 (PDCD5) has been proposed to put the brakes on uncontrolled cell proliferation by promoting apoptosis during tumorigenesis. A Mechanism for How Programmed Cell Death Protein 5 Promotes Apoptosis during Tumorigenesisࡗ
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