Abstract
1. 1. A kinetic study was carried out of the aggregation of fibrin monomers under different reaction conditions. 2. 2. At either acid or base pH values, second-order kinetic processes were observed throughout the concentration range studied. 3. 3. At neutral pH (6.8 ⩽ pH ⩽ 7.3) the kinetics were of second order at fibrin monomer concentrations of less than 0.3–0.4 mg/ml, while at higher concentrations they changed to first order. 4. 4. Both the second order rate constants and the opacity of the fibrin gels are highly dependent on pH, ionic strength, the concentration of calcium ions and on temperature. 5. 5. A three-step reaction mechanism is proposed for the aggregation of fibrin monomers to explain the kinetic behaviour observed in the different reaction media.
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